Functionalized carbon nanotubes for plasmid DNA gene delivery

Angewandte Chemie International Edition, 2004, 116 (39), 5354-5358

Functionalized carbon nanotubes for plasmid DNA gene delivery

Davide Pantarotto, Ravi Singh, David McCarthy, Mathieu Erhardt, Jean-Paul Briand, Maurizio Prato, Kostas Kostarelos and Alberto Bianco

Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

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Functionalized carbon nanotubes for plasmid DNA gene delivery

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LAB PUBLICATIONSVIEW ALL

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative blood-brain barrier disruption

Leveraging nanoparticle protein coronae to advance plasma proteome profiling

An artefact-resilient wide bandwidth bi-directional graphene neural interface

Engineering of glioblastoma-derived biomimetic vesicles and their structural and molecular features

Longitudinal plasma nano-proteomics analysis reveals acute systemic responses to radiotherapy and predictive biomarkers of late toxicity

Accelerated Electromagnetic Simulation of MRI RF Interactions with Graphene Microtransistor-Based Neural Probes for Electrophysiology-fMRI Integration

Graphene oxide nanosheet trehalose-assisted lyophilization with enhanced stability and facile aqueous reconstitution for biopharmaceutical use

Music enhances lipid nanoparticle brain delivery and mRNA transfection in brain cells

Engineering of a graphene oxide-based 2D platform for immune activation and modulation

Graphene micro-transistor arrays reveal perfusion-dependent electrophysiological and haemodynamic signatures of cortical spreading depolarizations in ischaemic stroke

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