This work was a collaborative effort between the NanoOmics team and the Cancer Biomarker Centre at the Cancer Research UK Manchester Institute and aimed to explore the potential use of nanomaterials in liquid biopsies. This multidisciplinary project highlighted the potential exploitation of the biomolecule corona as a novel tool for the enrichment and analysis of disease-specific blood-circulating nucleic acids and opens up new possibilities for the multi-omic analysis of biological fluids.