Strategies to Promote Cancer Nanomedicine Clinical Performance

Speaker: Prof. Dr. Twan Lammers, Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Aachen, Germany 

Abstract: Nanomedicines are extensively used for cancer therapy. By delivering drug molecules more effectively and more selectively to pathological sites, nanomedicines assist in improving the balance between drug efficacy and toxicity. The tumor accumulation of nanomedicines is traditionally ascribed to the EPR effect, which is highly variable, both in animal models and in patients. To address issues associated with tumor targeting heterogeneity, and to advance cancer nanomedicine clinical translation, we are working on systems and strategies to monitor and modulate tumor-targeted drug delivery. In the present lecture, several of these strategies will be highlighted, including image-guided interventions to prime the tumor microenvironment, and the use of imaging and tissue biomarkers for patient stratification. Altogether, our work aims to establish rational and realistic ways forward towards improving the clinical impact of cancer nanomedicines.

THIS WAS AN IN-PERSON EVENT (No video available)