Advancing local therapies for glioblastoma through a multidisciplinary collaboration

Speaker: Dr. Chiara Bastiancich, Institute of NeuroPhysiopathology, France 

Abstract: Glioblastoma (GBM) remains incurable despite a multimodal treatment consisting in surgery, radiotherapy and oral chemotherapy with Temozolomide (Stupp protocol). Dr. Chiara Bastiancich’s current research focuses on dissecting the dynamic post-surgical microenvironment (SMe) to identify therapeutic targets and time windows for intervention. By combining advanced imaging, immunophenotyping, and localized nanomedicine-based drug delivery, her team has shown that transient blood-brain barrier disruption and pro-tumoral immune activation post-surgery contribute to recurrence. Her preclinical studies demonstrate that pairing local chemotherapy with systemic immunomodulation delays tumor regrowth and improves survival. This work paves the way for novel combinatory treatments that strategically exploit the SMe to prevent GBM relapse.

THIS WAS AN IN-PERSON EVENT (No video available)