Brain stimulation therapy

Graphene microelectrodes can be made highly porous increasing the electrochemical surface area. They have low impedance, extremely high charge injection limit, and outstanding stability, making them suitable for brain stimulation. We are working with our collaborators on the Graphene flagship and with Prof Kostas Kostarelos to develop graphene stimulating electrodes useful for closed-loop cortical stimulation in neocortical epilepsy and in neurological diseases that may benefit from deep brain stimulation therapy including temporal lobe epilepsy and Parkinson’s diseas

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bioRxiv, 2025, in press

Graphene micro-transistor arrays reveal perfusion-dependent electrophysiological and haemodynamic signatures of cortical spreading depolarizations in ischaemic stroke

S. Flaherty, A. Eladly, K. Hills, J. Merlini, E. Masvidal-Codina, E. Fernandez, X. Illa, E. Prats-Alfonso, E. Del Corro, J.A. Garrido, J. Meents, K. Kostarelos, S Allan, A. Guimerà-Brunet*, R.C. Wykes*

FULL ABSTRACT

Nature Reviews Clinical Oncology, 2025, 22

Targeting the glioblastoma resection margin with locoregional nanotechnologies

Thomas Kisby, Gerben R. Borst, David J. Coope, Kostas Kostarelos*

FULL ABSTRACT

Journal of Nanobiotechnology 23, 393 (2025)

Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells

Yingxian Chen, Vinicio Rosano, Neus Lozano, YuYoung Shin, Aleksandr Mironov, David Spiller, Cinzia Casiraghi, Kostas Kostarelos*, Sandra Vranic*

FULL ABSTRACT

bioRxiv, 2025, in press

An artefact-resilient wide bandwidth bidirectional graphene neural interface

Michał Prokop, Martín Esparza-Iaizzo, Eduard Masvidal-Codina, Xavi Illa, Neela K. Codadu, Daman Rathore, Nicola Ria, Kostas Kostarelos, Elena del Corro, Ramon Garcia-Cortadella, Rob C. Wykes, Anton Guimerà-Brunet*, Jose A. Garrido*

FULL ABSTRACT

bioRxiv, 2025, in press

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

Lorena F. Fernandes, Chariya Peeyatu, Ben R. Dickie, Yu Siong Ho, Lydia A. Thompson, Noelia Hernandez, Neus Lozano, Kostas Kostarelos*, Thomas Kisby*

FULL ABSTRACT

Nature Communications, 2025, 16, 3412

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma

Xinming Liu, Hanan Abmanhal-Masarweh, Olivia Iwanowytsch, Emmanuel Okwelogu, Kiana Arashvand, Konstantina Karabatsou, Pietro I D'Urso, Federico Roncaroli, Kostas Kostarelos, Thomas Kisby*, Marilena Hadjidemetriou*

FULL ABSTRACT

Nature Communications, 2025, 16, 2891

Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats

Nicola Ria, Ahmed Eladly, Eduard Masvidal, Xavi Illa, Anton Guimerà, Kate Hills, Ramon Garcia, Fikret Taygun Duvan, Samuel Flaherty, Michal Prokop, Rob. C Wykes*, Kostas Kostarelos*, Jose A. Garrido*

FULL ABSTRACT

Cell Reports Physical Science, 2025, 6, 1, 1102342

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Maria Stylianou, Thomas Kisby*, Despoina Despotopoulou, Helen Parker, Alexandra Thawley, Kiana Arashvand, Neus Lozano, Andrew S. MacDonald, Kostas Kostarelos*

FULL ABSTRACT

ACS Nano 2025, 19, 11, 10630–10717

Interfacing with the brain: How nanotechnology can contribute

Abdullah A. A. Ahmed, Nuria Alegret, Bethany Almeida, Ramon Alvarez-Puebla, Anne M. Andrews, Laura Ballerini, Juan J. Barrios-Capuchino, Charline Becker, Robert H. Blick, Shahin Bonakdar, Indranath Chakraborty, Xiaodong Chen, Jinwoo Cheon, Gerwin Chilla, Andre Luiz Coelho Conceicao, James Delehanty, Martin Dulle, Alexander L. Efros, Matthias Epple, Mark Fedyk, Neus Feliu, Miao Feng, Rafael Fernandez-Chacon, Irene Fernandez-Cuesta, Niels Fertig, Stephan Forster, Jose A. Garrido, Michael George, Andreas H. Guse, Norbert Hampp, Jann Harberts, Jili Han, Hauke R. Heekeren, Ulrich G. Hofmann, Malte Holzapfel, Hessam Hosseinkazemi, Yalan Huang, Patrick Huber, Taeghwan Hyeon, Sven Ingebrandt, Marcello Ienca, Armin Iske, Yanan Kang, Gregor Kasieczka, Dae-Hyeong Kim, Kostas Kostarelos, Jae-Hyun Lee, Kai-Wei Lin, Sijin Liu, Xin Liu, Yang Liu, Christian Lohr, Volker Mailander, Laura Maffongelli, Saad Megahed, Alf Mews, Marina Mutas, Leroy Nack, Nako Nakatsuka, Thomas G. Oertner, Andreas Offenhauser, Martin Oheim, Ben Otange, Ferdinand Otto, Enrico Patrono, Bo Peng, Alessandra Picchiotti, Filippo Pierini, Monika Potter-Nerger, Maria Pozzi, Arnd Pralle, Maurizio Prato, Bing Qi, Pedro Ramos-Cabrer, Ute Resch Genger, Norbert Ritter, Marten Rittner, Sathi Roy, Francesca Santoro, Nicolas W. Schuck, Florian Schulz, Erkin Seker, Marvin Skiba, Martin Sosniok, Holger Stephan, Ruixia Wang, Ting Wang, K. David Wegner, Paul S. Weiss, Ming Xu, Chenxi Yang, Seyed Shahrooz Zargarian, Yuan Zeng, Yaofeng Zhou, Dingcheng Zhu, Robert Zierold, Wolfgang J. Parak*

FULL ABSTRACT

Nature Reviews Chemistry, 2025, 9, 173–184

Biological and environmental degradation of two-dimensional materials

Sandra Vranic^, Rajendra Kurapati^, Kostas Kostarelos*, Alberto Bianco*

FULL ABSTRACT

Brain stimulation therapy

Brain stimulation therapy

LAB PUBLICATIONSVIEW ALL

Graphene micro-transistor arrays reveal perfusion-dependent electrophysiological and haemodynamic signatures of cortical spreading depolarizations in ischaemic stroke

Targeting the glioblastoma resection margin with locoregional nanotechnologies

Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells

An artefact-resilient wide bandwidth bidirectional graphene neural interface

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma

Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Interfacing with the brain: How nanotechnology can contribute

Biological and environmental degradation of two-dimensional materials

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Brain stimulation therapy

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LAB PUBLICATIONSVIEW ALL

Graphene micro-transistor arrays reveal perfusion-dependent electrophysiological and haemodynamic signatures of cortical spreading depolarizations in ischaemic stroke

Targeting the glioblastoma resection margin with locoregional nanotechnologies

Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells

An artefact-resilient wide bandwidth bidirectional graphene neural interface

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma

Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats

Engineering the glioblastoma microenvironment using TLR7/8 agonist-complexed graphene oxide nanosheets

Interfacing with the brain: How nanotechnology can contribute

Biological and environmental degradation of two-dimensional materials

PART OF

PART OF