Blood Biomarker Discovery

We use our Nanoomics Technology platform in order to discover molecular biomarkers in blood (using both preclinical models and human clinical samples), for a range of diseases and biomarker applications with an emphasis on the early detection of cancer and neurodegenerative diseases.

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arxiv, 2026, in press

Accelerated Electromagnetic Simulation of MRI RF Interactions with Graphene Microtransistor-Based Neural Probes for Electrophysiology-fMRI Integration

Suchit Kumar, Alejandro Labastida Ramirez, Samuel M Flaherty, Anton Guimera Brunet, Nerea Alvarez de Eulate, Kostas Kostarelos, Ben Dickie, Rob C Wykes, Louis Lemieux

FULL ABSTRACT

Carbon, 2026, 250, 121254

Graphene oxide nanosheet trehalose-assisted lyophilization with enhanced stability and facile aqueous reconstitution for biopharmaceutical use

Gloria Garcia-Ortega, Neus Lozano, Kostas Kostarelos

FULL ABSTRACT

Journal of Controlled Release 2025, 388, 114301

Music enhances lipid nanoparticle brain delivery and mRNA transfection in brain cells

Patricia Mora-Raimundo*, Alon Gilon, Haim Kadosh, Yuval Richtman, Mor Sela, Shanny Ackerman, Gal Chen, Ravit Abel, Shaked Kagan, Noga Sharf-Pauker, Or Gigi, Hanan Abumanhal-Masarweh, Utkarsh Tripathi, Malak Saada, Aviram Shemen, Daphna Link-Sourani, Jeny Shklover, Rola Farah, Tzipi Horowitz-Kraus, Marilena Hadjidemetriou, Kostas Kostarelos, Shani Stern, Avi Schroeder*

FULL ABSTRACT

Journal of Materials Chemistry B, in press

Engineering of a graphene oxide-based 2D platform for immune activation and modulation

Despoina Despotopoulou, Maria Stylianou, Luis Miguel Arellano, Thomas Kisby, Neus Lozano, Kostas Kostarelos*

FULL ABSTRACT

bioRxiv, 2025, in press

Graphene micro-transistor arrays reveal perfusion-dependent electrophysiological and haemodynamic signatures of cortical spreading depolarizations in ischaemic stroke

S. Flaherty, A. Eladly, K. Hills, J. Merlini, E. Masvidal-Codina, E. Fernandez, X. Illa, E. Prats-Alfonso, E. Del Corro, J.A. Garrido, J. Meents, K. Kostarelos, S Allan, A. Guimerà-Brunet*, R.C. Wykes*

FULL ABSTRACT

Nature Reviews Clinical Oncology, 2025, 22

Targeting the glioblastoma resection margin with locoregional nanotechnologies

Thomas Kisby, Gerben R. Borst, David J. Coope, Kostas Kostarelos*

FULL ABSTRACT

Journal of Nanobiotechnology 23, 393 (2025)

Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells

Yingxian Chen, Vinicio Rosano, Neus Lozano, YuYoung Shin, Aleksandr Mironov, David Spiller, Cinzia Casiraghi, Kostas Kostarelos*, Sandra Vranic*

FULL ABSTRACT

bioRxiv, 2025, in press

An artefact-resilient wide bandwidth bidirectional graphene neural interface

Michał Prokop, Martín Esparza-Iaizzo, Eduard Masvidal-Codina, Xavi Illa, Neela K. Codadu, Daman Rathore, Nicola Ria, Kostas Kostarelos, Elena del Corro, Ramon Garcia-Cortadella, Rob C. Wykes, Anton Guimerà-Brunet*, Jose A. Garrido*

FULL ABSTRACT

bioRxiv, 2025, in press

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

Lorena F. Fernandes, Chariya Peeyatu, Ben R. Dickie, Yu Siong Ho, Lydia A. Thompson, Noelia Hernandez, Neus Lozano, Kostas Kostarelos*, Thomas Kisby*

FULL ABSTRACT

Nature Communications, 2025, 16, 3412

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma

Xinming Liu, Hanan Abmanhal-Masarweh, Olivia Iwanowytsch, Emmanuel Okwelogu, Kiana Arashvand, Konstantina Karabatsou, Pietro I D'Urso, Federico Roncaroli, Kostas Kostarelos, Thomas Kisby*, Marilena Hadjidemetriou*

FULL ABSTRACT

Blood Biomarker Discovery

Blood Biomarker Discovery

LAB PUBLICATIONSVIEW ALL

Accelerated Electromagnetic Simulation of MRI RF Interactions with Graphene Microtransistor-Based Neural Probes for Electrophysiology-fMRI Integration

Graphene oxide nanosheet trehalose-assisted lyophilization with enhanced stability and facile aqueous reconstitution for biopharmaceutical use

Music enhances lipid nanoparticle brain delivery and mRNA transfection in brain cells

Engineering of a graphene oxide-based 2D platform for immune activation and modulation

Graphene micro-transistor arrays reveal perfusion-dependent electrophysiological and haemodynamic signatures of cortical spreading depolarizations in ischaemic stroke

Targeting the glioblastoma resection margin with locoregional nanotechnologies

Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells

An artefact-resilient wide bandwidth bidirectional graphene neural interface

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma

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Blood Biomarker Discovery

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LAB PUBLICATIONSVIEW ALL

Accelerated Electromagnetic Simulation of MRI RF Interactions with Graphene Microtransistor-Based Neural Probes for Electrophysiology-fMRI Integration

Graphene oxide nanosheet trehalose-assisted lyophilization with enhanced stability and facile aqueous reconstitution for biopharmaceutical use

Music enhances lipid nanoparticle brain delivery and mRNA transfection in brain cells

Engineering of a graphene oxide-based 2D platform for immune activation and modulation

Graphene micro-transistor arrays reveal perfusion-dependent electrophysiological and haemodynamic signatures of cortical spreading depolarizations in ischaemic stroke

Targeting the glioblastoma resection margin with locoregional nanotechnologies

Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells

An artefact-resilient wide bandwidth bidirectional graphene neural interface

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma

PART OF

PART OF