Angewandte Chemie International Edition, 2004, 116(39): 5354-5358
Functionalized carbon nanotubes for plasmid DNA gene delivery
Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.