Articles | 2004

Angewandte Chemie International Edition, 2004, 116(39): 5354-5358

Functionalized carbon nanotubes for plasmid DNA gene delivery

D. Pantarotto, R. Singh, D. McCarthy, M. Erhardt, J.P. Briand, M. Prato*, K. Kostarelos*, A. Bianco*

Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA-nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

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