Articles | 2012

Nanomedicine, 2012, 7(10): 1485-94

In vivo degradation of functionalized carbon nanotubes after stereotactic administration in the brain cortex

A.Nunes, C.Bussy, L.Gherardini, M.Meneghetti, M.A.Herrero, A.Bianco, M.Prato, T.Pizzorusso, K.T.Al-Jamal and K.Kostarelos*

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Carbon nanotubes (CNTs) are increasingly being utilized in neurological applications as components of implants, electrodes or as delivery vehicles. Any application that involves implantation or injection of CNTs into the CNS needs to address the distribution and fate of the material following interaction and residence within the neuronal tissue. Here we report a preliminary study investigating the fate and structural integrity of amino-functionalized CNTs following stereotactic administration in the brain cortex.