Articles | 2010

Nature Materials, 2010, 9(6): 485-490

Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging

S.Y.Hong, G.Tobias*, K.T.Al-Jamal, B.Ballesteros, H.Ali-Boucetta, S.Lozano-Perez, P.D.Nellist, R.B.Sim, C.Finucane, S.J.Mather, M.L.H.Green, K.Kostarelos*, B.G.Davis*

Functionalization of nanomaterials for precise biomedical function is an emerging trend in nanotechnology. Carbon nanotubes are attractive as multifunctional carrier systems because payload can be encapsulated in internal space whilst outer surfaces can be chemically modified. Yet, despite potential as drug delivery systems and radiotracers, such filled and functionalized carbon nanotubes have not been previously investigated in vivo. Here we report covalent functionalization of radionuclide-filled single-walled carbon nanotubes and their use as radioprobes.

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