Articles | 2010

Chemical Commununications, 2010, 46: 1494-1496

Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers

C.SamoriĀ, H.Ali-Boucetta, R.Sainz, C.Guo, F.M.Toma, C.Fabbro, T.da Ros, M.Prato*, K.Kostarelos*,A.Bianco*

Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.

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