Articles | 2012

Angewandte Chemie Int Ed, 2012, 51: 6389 –6393

Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

K.T.Al-Jamal, A.Nunes, L.Methven, H.Ali-Boucetta, S.Li, F.M.Toma, M.A.Herrero, W.T.Al-Jamal, H.M.M.ten Eikelder, J.Foster, S.Mather, M.Prato*, A.Bianco*, K.Kostarelos*

Several factors are expected to play a role in the in vivo fate of CNTs including the type of surface modification (physical coating versus chemical functionalization) and the degree of chemical functionalization. Since pharmacokinetic profiling of carbon-based nanomaterials is essential, both pharmacologically and toxicologically, this study attempts to determine the effect of the degree of MWNT chemical functionalization on their ensuing pharmacokinetic profile.

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