Articles | 2004

International Journal of Cancer, 2004, 112(4): 713-721

Binding and interstitial penetration of liposomes within avascular tumor spheroids

K. Kostarelos*, D. Emfietzoglou, A. Papakostas, W.H. Yang, A. Ballangrud and G. Sgouros*

The liposomal delivery of cancer therapeutics, including gene therapy vectors, is an area of intense study. Poor penetration of liposomes into interstitial tumor spaces remains a problem, however. In this work, the penetration of different liposomal formulations into prostate carcinoma spheroids was examined. Spheroid penetration was assessed by confocal microscopy of fluorescently labeled liposomes.

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